Overexpression of PGC-1α in aging muscle enhances a subset of young-like molecular patterns
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منابع مشابه
Overexpression of PGC‐1α in aging muscle enhances a subset of young‐like molecular patterns
PGC-1α is a transcriptional co-activator known as the master regulator of mitochondrial biogenesis. Its control of metabolism has been suggested to exert critical influence in the aging process. We have aged mice overexpressing PGC-1α in skeletal muscle to determine whether the transcriptional changes reflected a pattern of expression observed in younger muscle. Analyses of muscle proteins show...
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THE EFFECTS OF INTERVAL TRAINING INTENSITY ON SKELETAL MUSCLE PGC-1Α IN TYPE2 DIABETIC MALE RATS
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متن کاملErratum to “Overexpression of PGC-1α Increases Fatty Acid Oxidative Capacity of Human Skeletal Muscle Cells”
We investigated the effects of PGC-1α (peroxisome proliferator-activated receptor γ coactivator-1α) overexpression on the oxidative capacity of human skeletal muscle cells ex vivo. PGC-1α overexpression increased the oxidation rate of palmitic acid and mRNA expression of genes regulating lipid metabolism, mitochondrial biogenesis, and function in human myotubes. Basal and insulin-stimulated deo...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2018
ISSN: 1474-9718
DOI: 10.1111/acel.12707